EPInformer Reproducible is a pipeline available on Hugging Face designed for applications in biology and genomics, specifically focusing on gene expression and enhancer prediction. The tool provides pretrained checkpoints for a reproducible pipeline that is based on raw ENCODE data and operates across six cell lines: K562, GM12878, H1, HepG2, HUVEC, and NHEK. This platform addresses the need for reproducible modeling in regulatory genomics by offering models that can predict enhancer activity and gene expression from DNA sequence data.
1 + sqrt(H3K27ac·DNase)) activity from DNA sequence, and EPInformer_v2, a gene-expression model for RNA and CAGE data that utilizes the frozen encoder from the enhancer predictor as its sequence backbone. Performance results are reported for both enhancer encoding and gene expression prediction, using a 12-fold leave-chromosome-out approach and pooled Pearson R metrics across the supported cell lines.
EPInformer Reproducible is implemented in PyTorch and is distributed under the MIT License, making it open source. It is intended for researchers and practitioners in regulatory genomics and related fields who require reproducible pipelines and pretrained models for enhancer and gene expression prediction. The tool is delivered as a set of files and code hosted on Hugging Face, with access to model checkpoints and source code for further use or adaptation.
EPInformer Reproducible sits in PulseGate's Other AI category. It focuses on providing a reproducible pipeline and pretrained models for enhancer and gene expression prediction in genomics research. It is built as an open-source project for genomics researchers. EPInformer Reproducible is open source under the Open Source license. It runs on the web and the command line.
Behind EPInformer Reproducible is JiecongLin, and the product first shipped in 2026. Development happens publicly on GitHub with 57 stars and 1 commits in the last 90 days. Key capabilities include genomics prediction, gene expression modeling, and pretrained checkpoints.
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