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SaProt 650M AF2
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S6

SaProt 650M AF2

huggingface.co·Infrastructure

SaProt_650M_AF2 is a 650 million parameter transformer model developed by Westlake University. It is trained on both protein sequences and structural information derived from AlphaFold2. The model supports fill-mask and other protein representation learning tasks and is intended to help researchers better understand and design proteins by incorporating structural context directly into the language model.

Open SourceMIT
WebAPI
S
SaProt 650M AF2 preview
Visit huggingface.co↗
⭐4.2k
stars
🍴802
forks
✓2
features
📅2020
since

Overview

2 features

In the Foundation models & chat space, SaProt 650M AF2 takes a focused approach. It focuses on modeling protein sequences with awareness of 3D structure to improve predictions in bioinformatics and protein engineering. SaProt 650M AF2 is an open-source project aimed at bioinformatics researchers and computational biologists. The project is open source (MIT). SaProt 650M AF2 is available on the web and API.

Westlake University builds and maintains SaProt 650M AF2, and the product first shipped in 2020. The GitHub repository has been archived.

  • ✓Fill-mask
  • ✓Protein structure awareness

Tags

protein-language-modelstructure-awarebioinformaticsesm-basedprotein-design

AI capabilities

TextInference: LocalWeights: Open

Built with & integrations

Hosting
aws
Runs on
BrowserAPI-only

Trust & compliance

LicenseMIT
Verified signals
✓ HTTPS✓ Privacy Policy✓ Terms of Service✓ Open Source✓ Free tier✓ GitHub · ★ 4.2k
Legal
Privacy Policy →Terms of Service →

Recent events

Latest indexed changes and source events

  1. IndexedJul 21, 3:32 PM

    westlake-repl/SaProt_650M_AF2 verified by the PulseGate indexer

    Source: PulseGate indexerOpen ↗

Frequently asked questions about SaProt 650M AF2

What is SaProt 650M AF2?
SaProt 650M AF2 focuses on modeling protein sequences with awareness of 3D structure to improve predictions in bioinformatics and protein engineering. It is catalogued under Foundation models & chat on PulseGate.
Who should use SaProt 650M AF2?
SaProt 650M AF2 is an open-source project built for bioinformatics researchers and computational biologists.
Does SaProt 650M AF2 have a free plan?
Yes — SaProt 650M AF2 is open source under the MIT license and free to use.
What platforms does SaProt 650M AF2 run on?
SaProt 650M AF2 runs on the web and API.
Is SaProt 650M AF2 still active?
PulseGate's liveness checks currently classify SaProt 650M AF2 as active.
What tools are similar to SaProt 650M AF2?
Similar tools tracked by PulseGate include Mfv Safetensors Carsonpo, Esm2 T12 35M UR50D, and ESMFold2 Experimental.Mfv Safetensors CarsonpoEsm2 T12 35M UR50DESMFold2 Experimental
Who develops SaProt 650M AF2?
SaProt 650M AF2 is developed by Westlake University.
How long has SaProt 650M AF2 been around?
SaProt 650M AF2 first shipped in 2020.

At a glance

Pricing
Open Source
Platforms
Web
Languages
English
Open source
Yes · ★ 4.2k · archived
License
MIT
First seen
Jul 21, 2026
Activity
🟢 Active
Status
🟢 Active
Built for
Bioinformatics researchers and computational biologists
Model
Open source
Solves
Modeling protein sequences with awareness of 3D structure to improve predictions in bioinformatics and protein engineering.

Developer

Westlake University
Community-driven
↗ GitHub

Open source

View on GitHub →

⚠ Archived

⭐ Stars
4,168
🍴 Forks
802
Open issues
115
Last commit
2y ago
Commits 90d
0
Contributors
29
Authorship
Community-driven
Default branch
main
Latest release
v1.0.3 · 4y ago

Live coverage

Confidence
Medium · 70
Indexed
Jul 21, 2026
Lifecycle
Alive
Activity
Active
First seen
Jul 2026
Last seen
today
Identity audit (10)
Entity ID
cmrutbj4v07ajqoarwo6to46h
Slug
westlake-repl-saprot-650m-af2-huggingface-co
Lifecycle last checked
Jul 21, 2026
Verification state
Indexed for public listing
Claim / listing state
Unclaimed · listed: yes
Index status
Included in index
Latest evidence snapshot
Jul 21, 2026
Timeline basis
Indexed-at chronology (no inferred launch/funding milestones).
Last updated
Jul 21, 2026
Canonical URL
https://huggingface.co/westlake-repl/SaProt_650M_AF2

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  • ESMFold2 Experimental
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  • Esm2 T30 150M UR50D
    huggingface.co
  • ESMFold2 Fast
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  • Sam2 Hiera Base Plus
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