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ESMplusplus Small
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ESMplusplus Small

huggingface.co·Infrastructure

ESMplusplus_small is a small-scale protein language model based on the ESM architecture, designed for fill-mask prediction on biological sequences. It enables researchers to perform protein property prediction, sequence generation, and related bioinformatics tasks. The model is hosted on Hugging Face and integrates with the Transformers library.

Open Source
WebCLIAPI
E
ESMplusplus Small preview
Visit huggingface.co↗
⭐49
stars
🍴9
forks
✓3
features
📅2024
since

Overview

3 features

In the Foundation models & chat space, ESMplusplus Small takes a focused approach. It focuses on predicting protein sequences and properties using masked language modeling without building a custom biological model. It is built as an open-source project for developers. ESMplusplus Small is open source under the Open Source license. It runs on the web, the command line, and API.

Synthyra builds and maintains ESMplusplus Small, and the product first shipped in 2024. Development happens publicly on GitHub with 49 stars and 68 commits in the last 90 days. Key capabilities include Protein Modeling, fill-Mask, and Biological Sequences.

  • ✓Protein Modeling
  • ✓Fill-Mask
  • ✓Biological Sequences

Tags

protein-language-modelesmbiology-aifill-mask

AI capabilities

TextInference: LocalWeights: Open

Built with & integrations

Hosting
aws
Runs on
BrowserCLIAPI-only

Trust & compliance

LicenseOpen Source
Verified signals
✓ HTTPS✓ Privacy Policy✓ Terms of Service✓ Open Source✓ GitHub · ★ 49✓ Active maintenance
Legal
Privacy Policy →Terms of Service →

Recent events

Latest indexed changes and source events

  1. IndexedJul 21, 1:01 PM

    Synthyra/ESMplusplus_small verified by the PulseGate indexer

    Source: PulseGate indexerOpen ↗

Frequently asked questions about ESMplusplus Small

What does ESMplusplus Small do?
ESMplusplus Small focuses on predicting protein sequences and properties using masked language modeling without building a custom biological model. It is catalogued under Foundation models & chat on PulseGate.
Who is ESMplusplus Small for?
ESMplusplus Small is an open-source project built for developers.
Is ESMplusplus Small free?
Yes — ESMplusplus Small is open source under the Open Source license and free to use.
What platforms does ESMplusplus Small run on?
ESMplusplus Small runs on the web, the command line, and API.
Is ESMplusplus Small still maintained?
PulseGate's liveness checks currently classify ESMplusplus Small as active. The GitHub repository shows 68 commits in the last 90 days.
What are alternatives to ESMplusplus Small?
Similar tools tracked by PulseGate include Esm2 T30 150M UR50D, ESMC 6B, and Esm2 T36 3B UR50D.Esm2 T30 150M UR50DESMC 6BEsm2 T36 3B UR50D
Who makes ESMplusplus Small?
ESMplusplus Small is developed by Synthyra.
When did ESMplusplus Small launch?
ESMplusplus Small first shipped in 2024.

At a glance

Pricing
Open Source
Platforms
Cli · Web
Languages
English
Open source
Yes · ★ 49
License
Open Source
First seen
Oct 12, 2025
Activity
🟢 Active
Status
🟢 Active
Built for
developers
Model
Open source
Solves
Predicting protein sequences and properties using masked language modeling without building a custom biological model.

Developer

Synthyra
Team
↗ GitHub

Open source

View on GitHub →
⭐ Stars
49
🍴 Forks
9
Open issues
1
Last commit
1d ago
Commits 90d
68
Contributors
6
Authorship
Team
Default branch
main

Live coverage

Confidence
Medium · 70
Indexed
Jul 21, 2026
Lifecycle
Alive
Activity
Active
First seen
Oct 2025
Last seen
today
Identity audit (10)
Entity ID
cmrunxtsr008icjzrjq5s65ou
Slug
synthyra-esmplusplus-small-huggingface-co
Lifecycle last checked
Jul 21, 2026
Verification state
Indexed for public listing
Claim / listing state
Unclaimed · listed: yes
Index status
Included in index
Latest evidence snapshot
Jul 21, 2026
Timeline basis
Indexed-at chronology (no inferred launch/funding milestones).
Last updated
Jul 21, 2026
Canonical URL
https://huggingface.co/Synthyra/ESMplusplus_small

Similar apps

Other apps tracked under the same category.

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  • Esm2 T36 3B UR50D
    huggingface.co
  • Esm2 T12 35M UR50D
    huggingface.co
  • Multilingual E5 Small
    huggingface.co
  • E5 Small
    huggingface.co